RESUMO
O Diabetes Mellitus (DM) é um problema de saúde pública em crescente expansão, frente aos maus hábitos alimentares, estilo de vida sedentário e estresse ambiental vivido na sociedade moderna. O presente estudo objetiva avaliar, em um município rural do Meio Oeste do Estado de Santa Catarina, a prevalência de nefropatia diabética, bem como os fatores de risco associados ao seu desenvolvimento. Tratou-se de estudo transversal de base populacional cuja amostra foi composta por diabéticos residentes no município (n = 85). Como variável dependente foram considerados os estágios da Doença Renal através de estimativa da Taxa de Filtração Glomerular (TFG). As variáveis independentes foram: idade, sexo, índice de massa corporal, uso ou não de insulina, níveis de hemoglobina glicosilada e risco cardiovascular. As mulheres representaram 55,29% (n = 47) da amostra. Neste grupo houve um risco significativamente maior para o desenvolvimento do estágio 3B da Doença Renal Crônica (OR = 9,34; IC 95% = 1,14 - 76,38). Aqueles com idade entre 70 e 79 anos possuiam um risco aumentado para o estágio 3A (OR = 2,89; IC 95% = 1,09 - 7,63). Ainda, aqueles pacientes com risco cardivascular moderado (entre 10% a 20%) tinham maior risco para o desenvolvimento do estágio 3A (OR = 3,90; IC 95% = 1,35 - 11,25). Dadas as complicações microvasculares do DM, em especial a nefropatia, é necessário buscar meios para que a imensa maioria destes pacientes tenha identificada a sua função renal. Os grupos de maior risco para o desenvolvimento da nefropatia diabética foram representados neste estudo pelas mulheres, por aqueles com idade entre 70 e 79 anos, pelos que tinham baixo índice de massa corpórea e nos que tinham risco cardiovascular entre 10 e 20%.
Diabetes Mellitus (DM) is a public health problem and is becoming increasingly widespread, compared to poor eating habits, sedentary lifestyle and environmental stress experienced in modern society. This study aims to evaluate, in a rural municipality of the Midwest State of Santa Catarina, the prevalence of diabetic nephropathy, as well as the risk factors associated with its development. This was a population-based cross-sectional study whose sample consisted of diabetic patients living in the municipality (n = 85). The dependent variable where the renal disease stages, evaluated trough the glomerular filtration rate. Independent variables were: age, sex, body mass index, use or not of insulin, glycosylated hemoglobin and cardiovascular risk. Women represented 55.29% (n = 47) of the sample. In this group there was a significantly higher risk for the development of 3B stage of chronic kidney disease (OR = 9.34; 95% CI 1.14 - 76.38). Those aged 70 to 79 possessed an increased risk for stage 3A (OR = 2.89; 95% CI = 1,09 - 7,63). Still, those patients with moderate cardiovascular risk (between 10% and 20%) had a higher risk for the development stage 3A (OR = 3.90; 95% CI 1.35 - 11.25). Given the microvascular complications of diabetes, especially nephropathy, it is necessary to seek ways for the vast majority of these patients have identified your kidney function. The high-risk groups for the development of diabetic nephropathy in this study were represented by women, for those aged 70 to 79 years, those who had low body mass index and among those with cardiovascular risk between 10 and 20%.
RESUMO
Aims: Cancer is a genetic disease characterized by an unbalance between cell growth and regulatory factors. The gene XRCC3 encodes a protein that contributes to the integrity of the genome and XRCC3 Thr241Met variants have their capacity of repair altered. Study Design: Our goal was to evaluate XRCC3 241Met polymorphism in a sample of cancer patients in the city of Macapá. Place and Duration of Study: Laboratory of Molecular Biology (Biological Sciences Program of the Federal University of Amapá), Dr. Alberto Lima Clinical Hospital (Hcal) and Institute of Hematology and Hemotherapy of Amapá between June 2009 and July 2010. Methodology: We analyzed 100 DNA samples of patients (50 cases diagnosed with cancer and 50 controls). DNA samples were amplified and analyzed by PCR-RFLP with the enzyme NLaIII. Results: The molecular analysis revealed that 58% of cases and 12% of controls had the Thr/Met genotype, while 82% of controls and 36% of cases had the Thr/Thr genotype. Conclusion: Non-invasive independent predictors for screening esophageal varices may decrease medical as well as financial burden, hence improving the management of cirrhotic patients. These predictors, however, need further work to validate reliability. The frequency of the Thr/Met genotype was higher among cancer patients when compared to the control group. Our findings suggest that XRCC3 241Met polymorphism may be associated with the risk cancer in the study population.